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Efficacy of MEK Inhibition in Patients with Histiocytic Neoplasms
Histiocytic neoplasms are a heterogeneous group of clonal hematopoietic disorders marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway.(1,2) For the 50% of histiocytosis patients with BRAFV600-mutations(3–5), RAF inhibition is highly efficacious and has dramatically alt...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6438729/ https://ncbi.nlm.nih.gov/pubmed/30867592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1012-y |
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