Efficacy of MEK Inhibition in Patients with Histiocytic Neoplasms

Histiocytic neoplasms are a heterogeneous group of clonal hematopoietic disorders marked by diverse mutations in the mitogen-activated protein kinase (MAPK) pathway.(1,2) For the 50% of histiocytosis patients with BRAFV600-mutations(3–5), RAF inhibition is highly efficacious and has dramatically alt...

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Gepubliceerd in:Nature
Hoofdauteurs: Diamond, Eli L., Durham, Benjamin H., Ulaner, Gary A, Drill, Esther, Buthorn, Justin, Ki, Michelle, Bitner, Lillian, Cho, Hana, Young, Robert J., Francis, Jasmine H, Rampal, Raajit, Lacouture, Mario, Brody, Lynn A., Ozkaya, Neval, Dogan, Ahmet, Rosen, Neal, Iasonos, Alexia, Abdel-Wahab, Omar, Hyman, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438729/
https://ncbi.nlm.nih.gov/pubmed/30867592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1012-y
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