Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia

Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder characterized by somatic BRAFV600E mutations. The malignant cell in HCL has immunophenotypic features of a mature B cell, but no normal counterpart along the continuum of developing B lymphocytes has been delineated as the cell of o...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Chung, Stephen S., Kim, Eunhee, Park, Jae H., Chung, Young Rock, Lito, Piro, Teruya-Feldstein, Julie, Hu, Wenhuo, Beguelin, Wendy, Monette, Sebastien, Duy, Cihangir, Rampal, Raajit, Telis, Leon, Patel, Minal, Kim, Min Kyung, Huberman, Kety, Bouvier, Nancy, Berger, Michael F., Melnick, Ari M., Rosen, Neal, Tallman, Martin S., Park, Christopher Y., Abdel-Wahab, Omar
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501573/
https://ncbi.nlm.nih.gov/pubmed/24871132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008004
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