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Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells

ATP7B is a copper-transporting P(1B)-type ATPase (Cu-ATPase) with an essential role in human physiology. Mutations in ATP7B cause the potentially fatal Wilson disease, and changes in ATP7B expression are observed in several cancers. Despite its physiologic importance, the biochemical information abo...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Jayakanthan, Samuel, Braiterman, Lelita T., Hasan, Nesrin M., Unger, Vinzenz M., Lutsenko, Svetlana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704462/
https://ncbi.nlm.nih.gov/pubmed/28842499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.807263
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