The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics

The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepatoneurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the mol...

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Foilsithe in:J Biol Chem
Main Authors: Yu, Corey H., Yang, Nan, Bothe, Jameson, Tonelli, Marco, Nokhrin, Sergiy, Dolgova, Natalia V., Braiterman, Lelita, Lutsenko, Svetlana, Dmitriev, Oleg Y.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2017
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672040/
https://ncbi.nlm.nih.gov/pubmed/28900031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811752
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