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The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics
The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepatoneurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the mol...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5672040/ https://ncbi.nlm.nih.gov/pubmed/28900031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811752 |
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