The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics

The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepatoneurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the mol...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Yu, Corey H., Yang, Nan, Bothe, Jameson, Tonelli, Marco, Nokhrin, Sergiy, Dolgova, Natalia V., Braiterman, Lelita, Lutsenko, Svetlana, Dmitriev, Oleg Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
Onderwerpen:
Protein Structure and Folding
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672040/
https://ncbi.nlm.nih.gov/pubmed/28900031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811752
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items