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The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin
Wilson disease ATPase (ATP7B) has been implicated in the resistance of cancer cells to cisplatin. Using a simple in vivo assay in bacterial culture, in the present study we demonstrate that ATP7B can confer resistance to cisplatin by sequestering the drug in its N-terminal metal-binding domain witho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825889/ https://ncbi.nlm.nih.gov/pubmed/19173677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081359 |
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