The Lumenal Loop Met(672)–Pro(707) of Copper-transporting ATPase ATP7A Binds Metals and Facilitates Copper Release from the Intramembrane Sites

The copper-transporting ATPase ATP7A has an essential role in human physiology. ATP7A transfers the copper cofactor to metalloenzymes within the secretory pathway; inactivation of ATP7A results in an untreatable neurodegenerative disorder, Menkes disease. Presently, the mechanism of ATP7A-mediated c...

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Autores principales: Barry, Amanda N., Otoikhian, Adenike, Bhatt, Sujata, Shinde, Ujwal, Tsivkovskii, Ruslan, Blackburn, Ninian J., Lutsenko, Svetlana
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143623/
https://ncbi.nlm.nih.gov/pubmed/21646353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229039
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