Interactions between Copper-binding Sites Determine the Redox Status and Conformation of the Regulatory N-terminal Domain of ATP7B

Copper-transporting ATPase ATP7B is essential for human copper homeostasis and normal liver function. ATP7B has six N-terminal metal-binding domains (MBDs) that sense cytosolic copper levels and regulate ATP7B. The mechanism of copper sensing and signal integration from multiple MBDs is poorly under...

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Main Authors: LeShane, Erik S., Shinde, Ujwal, Walker, Joel M., Barry, Amanda N., Blackburn, Ninian J., Ralle, Martina, Lutsenko, Svetlana
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Membrane Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825428/
https://ncbi.nlm.nih.gov/pubmed/20032459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074633
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