Interactions between Metal-binding Domains Modulate Intracellular Targeting of Cu(I)-ATPase ATP7B, as Revealed by Nanobody Binding

The biologically and clinically important membrane transporters are challenging proteins to study because of their low level of expression, multidomain structure, and complex molecular dynamics that underlies their activity. ATP7B is a copper transporter that traffics between the intracellular compa...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Huang, Yiping, Nokhrin, Sergiy, Hassanzadeh-Ghassabeh, Gholamreza, Yu, Corey H., Yang, Haojun, Barry, Amanda N., Tonelli, Marco, Markley, John L., Muyldermans, Serge, Dmitriev, Oleg Y., Lutsenko, Svetlana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239620/
https://ncbi.nlm.nih.gov/pubmed/25253690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.580845
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