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The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics

The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepatoneurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the mol...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Yu, Corey H., Yang, Nan, Bothe, Jameson, Tonelli, Marco, Nokhrin, Sergiy, Dolgova, Natalia V., Braiterman, Lelita, Lutsenko, Svetlana, Dmitriev, Oleg Y.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672040/
https://ncbi.nlm.nih.gov/pubmed/28900031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811752
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