Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many pathways have been implicated in stretch-induced remodeling, the control structures by which signals from distinct mechano-sensors are integrated to modulate hypertrophy and gene expression in cardiomyocytes rem...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Tan, Philip M., Buchholz, Kyle S., Omens, Jeffrey H., McCulloch, Andrew D., Saucerman, Jeffrey J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703578/
https://ncbi.nlm.nih.gov/pubmed/29131824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005854
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