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Cell-to-cell variation sets a tissue-rheology–dependent bound on collective gradient sensing

When a single cell senses a chemical gradient and chemotaxes, stochastic receptor–ligand binding can be a fundamental limit to the cell’s accuracy. For clusters of cells responding to gradients, however, there is a critical difference: Even genetically identical cells have differing responses to che...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Camley, Brian A., Rappel, Wouter-Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703308/
https://ncbi.nlm.nih.gov/pubmed/29114053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712309114
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