Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal muscle mass, which have been reported to primarily signal via the ActRIIB receptor on skeletal muscle and thereby induce muscle wasting described as cachexia. Use of a soluble ActRIIB-Fc “trap,” to block myos...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Morvan, Frederic, Rondeau, Jean-Michel, Zou, Chao, Minetti, Giulia, Scheufler, Clemens, Scharenberg, Meike, Jacobi, Carsten, Brebbia, Pascale, Ritter, Veronique, Toussaint, Gauthier, Koelbing, Claudia, Leber, Xavier, Schilb, Alain, Witte, Florian, Lehmann, Sylvie, Koch, Elke, Geisse, Sabine, Glass, David J., Lach-Trifilieff, Estelle
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703284/
https://ncbi.nlm.nih.gov/pubmed/29109273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707925114
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