Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

The TGF-β family ligands myostatin, GDF11, and activins are negative regulators of skeletal muscle mass, which have been reported to primarily signal via the ActRIIB receptor on skeletal muscle and thereby induce muscle wasting described as cachexia. Use of a soluble ActRIIB-Fc “trap,” to block myos...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Morvan, Frederic, Rondeau, Jean-Michel, Zou, Chao, Minetti, Giulia, Scheufler, Clemens, Scharenberg, Meike, Jacobi, Carsten, Brebbia, Pascale, Ritter, Veronique, Toussaint, Gauthier, Koelbing, Claudia, Leber, Xavier, Schilb, Alain, Witte, Florian, Lehmann, Sylvie, Koch, Elke, Geisse, Sabine, Glass, David J., Lach-Trifilieff, Estelle
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703284/
https://ncbi.nlm.nih.gov/pubmed/29109273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707925114
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