Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

Brown adipose tissue (BAT) is a key tissue for energy expenditure via fat and glucose oxidation for thermogenesis. In this study, we demonstrate that the myostatin/activin receptor IIB (ActRIIB) pathway, which serves as an important negative regulator of muscle growth, is also a negative regulator o...

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Main Authors: Fournier, Brigitte, Murray, Ben, Gutzwiller, Sabine, Marcaletti, Stefan, Marcellin, David, Bergling, Sebastian, Brachat, Sophie, Persohn, Elke, Pierrel, Eliane, Bombard, Florian, Hatakeyama, Shinji, Trendelenburg, Anne-Ulrike, Morvan, Frederic, Richardson, Brian, Glass, David J., Lach-Trifilieff, Estelle, Feige, Jerome N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416189/
https://ncbi.nlm.nih.gov/pubmed/22586266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06575-11
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