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Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA

BMP7 evokes acute chemotropic PI3K-dependent responses, such as growth cone collapse and monocyte chemotaxis, as well as classical Smad-dependent gene transcription. That these divergent responses can be activated in the same cell raises the question of how the BMP-dependent signaling apparatus is m...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Perron, Jeanette C., Rodrigues, Alcina A., Surubholta, Nirupama, Dodd, Jane
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679395/
https://ncbi.nlm.nih.gov/pubmed/31208997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.042283
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