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Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA

BMP7 evokes acute chemotropic PI3K-dependent responses, such as growth cone collapse and monocyte chemotaxis, as well as classical Smad-dependent gene transcription. That these divergent responses can be activated in the same cell raises the question of how the BMP-dependent signaling apparatus is m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biol Open
Hauptverfasser: Perron, Jeanette C., Rodrigues, Alcina A., Surubholta, Nirupama, Dodd, Jane
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679395/
https://ncbi.nlm.nih.gov/pubmed/31208997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.042283
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