Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH). Circulating levels of interleukin-1 (IL-1) are raised in patients and animal models. Whether interplay between BMP and IL-1 signaling can explain...

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Bibliographic Details
Published in:Pulm Circ
Main Authors: Pickworth, Josephine, Rothman, Alexander, Iremonger, James, Casbolt, Helen, Hopkinson, Kay, Hickey, Peter M., Gladson, Santhi, Shay, Sheila, Morrell, Nicholas W., Francis, Sheila E., West, James D., Lawrie, Allan
Format: Artigo
Language:Inglês
Published: SAGE Publications 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703124/
https://ncbi.nlm.nih.gov/pubmed/28828907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045893217729096
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