Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner

Inflammatory mechanisms are proposed to play a significant role in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have described PAH in fat-fed apolipoprotein E knockout (ApoE(−/−)) mice. We have reported that signaling in interleukin-1–receptor–knockout (IL-1R1(−/−)) mi...

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Main Authors: Lawrie, Allan, Hameed, Abdul G., Chamberlain, Janet, Arnold, Nadine, Kennerley, Aneurin, Hopkinson, Kay, Pickworth, Josephine, Kiely, David G., Crossman, David C., Francis, Sheila E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181351/
https://ncbi.nlm.nih.gov/pubmed/21835155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.037
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