Selective improvement of pulmonary arterial hypertension with a dual ET(A)/ET(B) receptors antagonist in the apolipoprotein E(−/−) model of PAH and atherosclerosis

Idiopathic pulmonary arterial hypertension (IPAH) is increasingly diagnosed in elderly patients who also have an increased risk of co-morbid atherosclerosis. Apolipoprotein E-deficient (ApoE(−/−)) mice develop atherosclerosis with severe PAH when fed a high-fat diet (HFD) and have increased levels o...

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Detalhes bibliográficos
Publicado no:Pulm Circ
Main Authors: Renshall, Lewis, Arnold, Nadine, West, Laura, Braithwaite, Adam, Pickworth, Josephine, Walker, Rachel, Alfaidi, Mabruka, Chamberlain, Janet, Casbolt, Helen, Thompson, A.A. Roger, Holt, Cathy, Iglarz, Marc, Francis, Sheila, Lawrie, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798688/
https://ncbi.nlm.nih.gov/pubmed/29261014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2045893217752328
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