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Proteasomal degradation unleashes the pro-death activity of androgen receptor

Androgen receptor (AR) is able to promote stress-induced cell death independently of its transcription activity in androgen-independent prostate cancer cells. Yet, the underlying mechanism is incompletely understood. Here, we report that stress-induced proteasomal degradation of AR contributes to it...

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Publicado en:Cell Res
Autores principales: Godfrey, Bradley, Lin, Yuting, Larson, Jeffery, Haferkamp, Bonnie, Xiang, Jialing
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702544/
https://ncbi.nlm.nih.gov/pubmed/20479785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.65
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