Nuclear Export Signal of Androgen Receptor (NES(AR)) Regulation of Androgen Receptor Level in Human Prostate Cell Lines via Ubiquitination and Proteasome-Dependent Degradation

Androgen receptor (AR) plays a key role in prostate development and carcinogenesis. Increased expression and/or stability of AR is associated with sensitization of prostate cancer cells to low levels of androgens, leading to castration resistance. Hence, understanding the mechanisms regulating AR pr...

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Bibliographische Detailangaben
Hauptverfasser: Gong, Yanqing, Wang, Dan, Dar, Javid A., Singh, Prabhpreet, Graham, Lara, Liu, Weijun, Ai, Junkui, Xin, Zhongcheng, Guo, Yinglu, Wang, Zhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Cancer-Oncogenes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512072/
https://ncbi.nlm.nih.gov/pubmed/23041672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1841
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