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The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process

In response to hormonal stimuli, a cascade of hierarchical post-translational modifications of nuclear receptors are required for the correct expression of target genes. Here, we show that the transcription factor TFIIH, via its cdk7 kinase, phosphorylates the androgen receptor (AR) at position AR/S...

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Autores principales: Chymkowitch, Pierre, Le May, Nicolas, Charneau, Pierre, Compe, Emmanuel, Egly, Jean-Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034013/
https://ncbi.nlm.nih.gov/pubmed/21157430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.337
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