Prospective diagnosis of sporadic CJD by the detection of abnormal PrP in patient urine

IMPORTANCE: CJD is a fatal neurodegenerative disorder associated with the accumulation of infectious abnormal PrP through a mechanism of templated misfolding. A recent report has described the detection of abnormal PrP in vCJD patient urine using protein misfolding by cylic amplification, which was...

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Udgivet i:JAMA Neurol
Main Authors: Luk, Connie, Jones, Samantha, Thomas, Claire, Fox, Nick C, Mok, Tze H, Mead, Simon, Collinge, John, Jackson, Graham S
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701732/
https://ncbi.nlm.nih.gov/pubmed/27699415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.3733
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