FGFR2 amplification in colorectal adenocarcinoma

FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen. Preclinical studies indicate that several FGFR tyrosine-kinase inhibitors (TKIs), such as AZD4547, have in vitro ac...

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Bibliographic Details
Published in:Cold Spring Harb Mol Case Stud
Main Authors: Carter, Jamal H., Cottrell, Catherine E., McNulty, Samantha N., Vigh-Conrad, Katinka A., Lamp, Stephen, Heusel, Jonathan W., Duncavage, Eric J.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701301/
https://ncbi.nlm.nih.gov/pubmed/28835367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001495
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