High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial

FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high response rate to the selective FGFR inhibitor AZD...

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Vydáno v:Cancer Discov
Hlavní autoři: Pearson, Alex, Smyth, Elizabeth, Babina, Irina S., Herrera-Abreu, Maria Teresa, Tarazona, Noelia, Peckitt, Clare, Kilgour, Elaine, Smith, Neil R., Geh, Catherine, Rooney, Claire, Cutts, Ros, Campbell, James, Ning, Jian, Fenwick, Kerry, Swain, Amanda, Brown, Gina, Chua, Sue, Thomas, Anne, Johnston, Stephen R.D., Ajaz, Mazhar, Sumpter, Katherine, Gillbanks, Angela, Watkins, David, Chau, Ian, Popat, Sanjay, Cunningham, David, Turner, Nicholas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338732/
https://ncbi.nlm.nih.gov/pubmed/27179038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1246
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