Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon

FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected FGFR1 amplified patients by FISH. Lung cancer cell lines were profiled for sensitivity to AZD4547, a potent, selective inhibitor of FGFRs 1–3. Sensitivity to FGFR inhibition was associated with but not wholly...

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Publicat a:PLoS One
Autors principals: Rooney, Claire, Geh, Catherine, Williams, Victoria, Heuckmann, Johannes M., Menon, Roopika, Schneider, Petra, Al-Kadhimi, Katherine, Dymond, Michael, Smith, Neil R., Baker, Dawn, French, Tim, Smith, Paul D., Harrington, Elizabeth A., Barrett, J. Carl, Kilgour, Elaine
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764357/
https://ncbi.nlm.nih.gov/pubmed/26905262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149628
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