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Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening

Alzheimer disease and related dementias are major challenges, demanding urgent needs for earliest possible diagnosis to optimize the success rate in finding effective therapeutic interventions. Mounting solid scientific premises point at the core acetylcholine-biosynthesizing cholinergic enzyme, ChA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kumar, Rajnish, Kumar, Amit, Långström, Bengt, Darreh-Shori, Taher
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701137/
https://ncbi.nlm.nih.gov/pubmed/29176551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16033-w
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