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Discovery of novel allosteric Eg5 inhibitors through structure-based virtual screening

Mitotic kinesin Eg5 is an attractive anti-cancer drug target. Discovery of Eg5 inhibitors has been focused on targeting the “monastrol-binding site”. However, acquired drug resistance has been reported for such inhibitors. Therefore, identifying new Eg5 inhibitors which function through a different...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Chem Biol Drug Des
Main Authors: Zhang, Wei, Zhai, Ling, Lu, Wenyan, Boohaker, Rebecca J., Padmalayam, Indira, Li, Yonghe
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936947/
https://ncbi.nlm.nih.gov/pubmed/26864917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12744
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