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Discovery of novel allosteric Eg5 inhibitors through structure-based virtual screening
Mitotic kinesin Eg5 is an attractive anti-cancer drug target. Discovery of Eg5 inhibitors has been focused on targeting the “monastrol-binding site”. However, acquired drug resistance has been reported for such inhibitors. Therefore, identifying new Eg5 inhibitors which function through a different...
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| Pubblicato in: | Chem Biol Drug Des |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4936947/ https://ncbi.nlm.nih.gov/pubmed/26864917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12744 |
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