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Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase
Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors. The p85 subunit of phosphatidylinositol 3-kinase (PI3K) is a GTPase...
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| Published in: | Sci Rep |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700975/ https://ncbi.nlm.nih.gov/pubmed/29170408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16029-6 |
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