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R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature

The formation of endothelial lumen is fundamental to angiogenesis and essential to the oxygenation of hypoxic tissues. The molecular mechanism underlying this important process remains obscure. Here, we show that Akt activation by a Ras homolog, R-Ras, stabilizes the microtubule cytoskeleton in endo...

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Publicat a:Nat Commun
Autors principals: Li, Fangfei, Sawada, Junko, Komatsu, Masanobu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700916/
https://ncbi.nlm.nih.gov/pubmed/29170374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01865-x
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