Small GTPase R-Ras regulates Integrity and Functionality of Tumor Blood Vessels

We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel struc...

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Main Authors: Sawada, Junko, Urakami, Takeo, Li, Fangfei, Urakami, Akane, Zhu, Weiquan, Fukuda, Minoru, Li, Dean Y., Ruoslahti, Erkki, Komatsu, Masanobu
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422514/
https://ncbi.nlm.nih.gov/pubmed/22897853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.06.013
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