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Small GTPase R-Ras regulates Integrity and Functionality of Tumor Blood Vessels
We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel struc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422514/ https://ncbi.nlm.nih.gov/pubmed/22897853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.06.013 |
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