Orchestration of DNA damage checkpoint dynamics across the human cell cycle

Although molecular mechanisms that prompt cell cycle arrest in response to DNA damage have been elucidated, the systems-level properties of DNA damage checkpoints are not understood. Here, using time-lapse microscopy and simulations that model the cell cycle as a series of Poisson processes, we char...

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Vydáno v:Cell Syst
Hlavní autoři: Chao, Hui Xiao, Poovey, Cere E., Privette, Ashley A., Grant, Gavin D., Chao, Hui Yan, Cook, Jeanette G., Purvis, Jeremy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700845/
https://ncbi.nlm.nih.gov/pubmed/29102360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.09.015
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