Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylation at serine 1292 (pS1292) and neurotoxicity in model systems. pS1292-LRRK2 protein can...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Wang, Shijie, Liu, Zhiyong, Ye, Tao, Mabrouk, Omar S., Maltbie, Tyler, Aasly, Jan, West, Andrew B.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700679/
https://ncbi.nlm.nih.gov/pubmed/29166931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0492-y
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