Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice

Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respectively. CD35 stimulates phagocytosis on macrophages and antigen presentation on follicular dendritic cells (FDCs). CD21 helps activate B cells as part of the B ce...

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Bibliographic Details
Published in:mSphere
Main Authors: Kane, Sarah J., Swanson, Eric, Gordon, Elizabeth O., Rocha, Savannah, Bender, Heather R., Donius, Luke R., Aguzzi, Adriano, Hannan, Jonathan P., Zabel, Mark D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700378/
https://ncbi.nlm.nih.gov/pubmed/29202042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphereDirect.00493-17
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