Genetic Depletion of Complement Receptors CD21/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease

The complement system has been shown to facilitate peripheral prion pathogenesis. Mice lacking complement receptors CD21/35 partially resist terminal prion disease when infected i.p. with mouse-adapted scrapie prions. Chronic wasting disease (CWD) is an emerging prion disease of captive and free-ran...

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Detalhes bibliográficos
Main Authors: Michel, Brady, Ferguson, Adam, Johnson, Theodore, Bender, Heather, Meyerett-Reid, Crystal, Pulford, Bruce, von Teichman, Adriana, Seelig, Davis, Weis, John H., Telling, Glenn C., Aguzzi, Adriano, Zabel, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2012
Assuntos:
Host Defense
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478448/
https://ncbi.nlm.nih.gov/pubmed/23002439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201579
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