Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance

Genetics-based drug susceptibility testing has improved the diagnosis of drug-resistant tuberculosis but is limited by our lack of knowledge of all resistance mechanisms. Next-generation sequencing has assisted in identifying the principal genetic mechanisms of resistance for many drugs, but a signi...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: de Welzen, Lynne, Eldholm, Vegard, Maharaj, Kashmeel, Manson, Abigail L., Earl, Ashlee M., Pym, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700317/
https://ncbi.nlm.nih.gov/pubmed/28993337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01461-17
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