ethA, inhA, and katG Loci of Ethionamide-Resistant Clinical Mycobacterium tuberculosis Isolates

Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA, an enzyme involved in mycolic acid biosynthesis. INH requires catalase-peroxidase (KatG) activation, and mutations in katG are a major INH resistance mechanism. Recently an enzyme...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Morlock, Glenn P., Metchock, Beverly, Sikes, David, Crawford, Jack T., Cooksey, Robert C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2003
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296216/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14638486/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.12.3799-3805.2003
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