ethA, inhA, and katG Loci of Ethionamide-Resistant Clinical Mycobacterium tuberculosis Isolates

Ethionamide (ETH) is a structural analog of the antituberculosis drug isoniazid (INH). Both of these drugs target InhA, an enzyme involved in mycolic acid biosynthesis. INH requires catalase-peroxidase (KatG) activation, and mutations in katG are a major INH resistance mechanism. Recently an enzyme...

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Détails bibliographiques
Auteurs principaux: Morlock, Glenn P., Metchock, Beverly, Sikes, David, Crawford, Jack T., Cooksey, Robert C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC296216/
https://ncbi.nlm.nih.gov/pubmed/14638486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.12.3799-3805.2003
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