Detection of Isoniazid-Resistant Mycobacterium tuberculosis Strains by a Multiplex Allele-Specific PCR Assay Targeting katG Codon 315 Variation

We describe a simple multiplex allele-specific (MAS)-PCR assay to detect mutations in the second base of the katG gene codon 315, including AGC→ACC and ACA (Ser→Thr) substitutions that confer resistance to isoniazid (INH) in Mycobacterium tuberculosis clinical isolates. The 315 ACC allele is found i...

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Detalhes bibliográficos
Main Authors: Mokrousov, Igor, Otten, Tatiana, Filipenko, Maxim, Vyazovaya, Anna, Chrapov, Eugeny, Limeschenko, Elena, Steklova, Lidia, Vyshnevskiy, Boris, Narvskaya, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC120554/
https://ncbi.nlm.nih.gov/pubmed/12089271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.7.2509-2512.2002
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