Genetic Deletion of Sost or Pharmacological Inhibition of Sclerostin Prevent Multiple Myeloma-induced Bone Disease without Affecting Tumor Growth

Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and concomitant marked suppression of bone formation. Sclerostin (Scl) levels, an osteocyte-derived inhibitor of Wnt/β-catenin signaling, are elevated in MM patient sera and are increased in osteocytes in MM-bearing mic...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Delgado-Calle, Jesus, Anderson, Judith, Cregor, Meloney D., Condon, Keith W., Kuhstoss, Stuart A., Plotkin, Lilian I., Bellido, Teresita, Roodman, G. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699973/
https://ncbi.nlm.nih.gov/pubmed/28529307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.152
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