Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We show here that Notch3 inhibition in MM cells...

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Detalhes bibliográficos
Main Authors: Hayley M. Sabol, Tânia Amorim, Cody Ashby, David Halladay, Judith Anderson, Meloney Cregor, Megan Sweet, Intawat Nookaew, Noriyoshi Kurihara, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-06-01
Colecção:Neoplasia: An International Journal for Oncology Research
Assuntos:
Notch
Osteocytes
Myeloma
Cancer
Bone
Tumor microenvironment
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558622000148
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