Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling

Excess of glucocorticoids (GCs) is a leading cause of bone fragility, and therapeutic targets are sorely needed. We report that genetic deletion or pharmacological inhibition of proline-rich tyrosine kinase 2 (Pyk2) prevents GC-induced bone loss by overriding GC effects of detachment-induced bone ce...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Sato, Amy Y, Cregor, Meloney, McAndrews, Kevin, Li, Troy, Condon, Keith W, Plotkin, Lilian I, Bellido, Teresita
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591015/
https://ncbi.nlm.nih.gov/pubmed/31081900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00237
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