Genetic Deletion of Sost or Pharmacological Inhibition of Sclerostin Prevent Multiple Myeloma-induced Bone Disease without Affecting Tumor Growth

Multiple myeloma (MM) causes lytic bone lesions due to increased bone resorption and concomitant marked suppression of bone formation. Sclerostin (Scl) levels, an osteocyte-derived inhibitor of Wnt/β-catenin signaling, are elevated in MM patient sera and are increased in osteocytes in MM-bearing mic...

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Bibliografiske detaljer
Udgivet i:Leukemia
Main Authors: Delgado-Calle, Jesus, Anderson, Judith, Cregor, Meloney D., Condon, Keith W., Kuhstoss, Stuart A., Plotkin, Lilian I., Bellido, Teresita, Roodman, G. David
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699973/
https://ncbi.nlm.nih.gov/pubmed/28529307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.152
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