Defects in Recombination Activity Caused by Somatic and Germline Mutations in the Multimerization/BRCA2 Binding Region of Human RAD51 Protein

The human RAD51 recombinase possesses DNA pairing and strand exchange activities that are essential for the error-free, homology-directed repair of DNA double-strand breaks. The recombination activities of RAD51 are activated upon its assembly into presynaptic filaments on single-stranded DNA at res...

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Vydáno v:DNA Repair (Amst)
Hlavní autoři: Silva, Michelle C., Bryan, Katie E., Morrical, Milagros D., Averill, April M., Dragon, Julie, Wiegmans, Adrian P., Morrical, Scott W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699509/
https://ncbi.nlm.nih.gov/pubmed/29100040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.10.008
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