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Purified human BRCA2 stimulates RAD51-mediated recombination
Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the difficulty of isolating this large protein (3,418 amino acids). Here we report purification of full length BRCA2 and show that...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952063/ https://ncbi.nlm.nih.gov/pubmed/20729832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09399 |
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