STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus

Cytokines critically control immune responses, but how regulatory programs are altered to allow T cells to differentially respond to distinct cytokine stimuli remains poorly understood. Here, we have globally analyzed enhancer elements bound by IL-2–activated STAT5 and IL-21–activated STAT3 in T cel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Peng, Mitra, Suman, Spolski, Rosanne, Oh, Jangsuk, Liao, Wei, Tang, Zhonghui, Mo, Fei, Li, Xingwang, West, Erin E., Gromer, Daniel, Lin, Jian-Xin, Liu, Chengyu, Ruan, Yijun, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699083/
https://ncbi.nlm.nih.gov/pubmed/29078395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714019114
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