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Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy
The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5699070/ https://ncbi.nlm.nih.gov/pubmed/29087330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712297114 |
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