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Exploring long-range cooperativity in the 20S proteasome core particle from Thermoplasma acidophilum using methyl-TROSY–based NMR

The 20S core particle (CP) proteasome is a molecular assembly catalyzing the degradation of misfolded proteins or proteins no longer required for function. It is composed of four stacked heptameric rings that form a barrel-like structure, sequestering proteolytic sites inside its lumen. Proteasome f...

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Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Rennella, Enrico, Huang, Rui, Yu, Zanlin, Kay, Lewis E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071895/
https://ncbi.nlm.nih.gov/pubmed/32094174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920770117
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